Molecules affecting hypothalamic control of core body temperature in response to calorie intake

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Molecules affecting hypothalamic control of core body temperature in response to calorie intake

Core body temperature (CBT) and calorie intake are main components of energy homeostasis and two important regulators of health, longevity, and aging. In homeotherms, CBT can be influenced by calorie intake as food deprivation or calorie restriction (CR) lowers CBT whereas feeding has hyperthermic effects. The finding that in mice CBT prolonged lifespan independently of CR, suggested that the m...

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Hypothalamic control of body temperature: insights from the past.

This essay looks at the historical significance of three APS classic papers that are freely available online: Hammel HT, Hardy JD, and Fusco MM. Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs. Am J Physiol 198: 481-486, 1960 (http://ajplegacy.physiology.org/cgi/reprint/198/3/481). Hammel HT, Jackson DC, Stolwijk JAJ, Hardy JD, and Stromme SB. Temperature regulation by...

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Hypothalamic control of food intake.

This brief review of the neural control of food intake is prepared as an introduction to this symposium and is not to be considered as a complete coverage of all the aspects of anatomy, physiology, behavioural and metabolic studies which have provided information on the influence of the hypothalamus on feeding behaviour. Readers who are interested in greater detail will find appropriate referen...

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Hypothalamic control of food intake

This brief review of the neural control of food intake is prepared as an introduction to this symposium and is not to be considered as a complete coverage of all the aspects of anatomy, physiology, behavioural and metabolic studies which have provided information on the influence of the hypothalamus on feeding behaviour. Readers who are interested in greater detail will find appropriate referen...

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Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans

Reduction of body temperature has been proposed to contribute to the increased lifespan in calorie restricted animals and mice overexpressing the uncoupling protein-2 in hypocretin neurons. However, nothing is known regarding the long-term effects of calorie restriction (CR) with adequate nutrition on body temperature in humans. In this study, 24-hour core body temperature was measured every mi...

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ژورنال

عنوان ژورنال: Frontiers in Genetics

سال: 2012

ISSN: 1664-8021

DOI: 10.3389/fgene.2012.00184